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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-3-1
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pubmed:abstractText |
We have compared the tumorigenicity of two src oncogenes, v-src and c-src(527), whose respective protein products pp60v-src and pp60c-src(527) show a different spectrum of amino acid substitutions vis-à-vis the c-src protooncogene-encoded product pp60c-src. Whereas the extent of primary tumor growth induced by c-src(527) was quite similar in the two chicken lines tested, the extent of v-src-induced tumor growth showed a marked line dependence. As examined with a line of chickens that shows immune-mediated regression of v-src-induced tumors, a weaker tumor immunity, as correlated with a greater level of primary tumor growth, resulted from inoculation of c-src(527) DNA than of v-src DNA. These observations indicated that the v-src-specific amino acid substitutions define a major tumor antigenicity. That a separate src-associated antigenicity is also targetable by the tumor immune response followed from the finding that the level of protective immunity against the growth of c-src(527) DNA-induced tumors was augmented under conditions of the prior regression of v-src DNA-induced tumors. As this latter antigenicity may include one or more c-src(527)-encoded peptides that are equivalent to c-src-encoded self peptides, these observations suggest that a host tolerance to pp60c-src can be broken so as to permit a tumor immune response based on recognition of self peptides of pp60c-src(527).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-1329333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-1348493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-1406974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-1658394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-2155515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-2257627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-2582237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-2840516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-6192323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-6300833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-7577802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-7909159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-8082891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-8212590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570642-8293461
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
824-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8570642-Animals,
pubmed-meshheading:8570642-Antigens, Neoplasm,
pubmed-meshheading:8570642-Chickens,
pubmed-meshheading:8570642-Genes, src,
pubmed-meshheading:8570642-Immunity,
pubmed-meshheading:8570642-Major Histocompatibility Complex,
pubmed-meshheading:8570642-Neoplasms, Experimental,
pubmed-meshheading:8570642-Oncogene Protein pp60(v-src),
pubmed-meshheading:8570642-Proto-Oncogene Proteins pp60(c-src)
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pubmed:year |
1996
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pubmed:articleTitle |
Endogenous c-src as a determinant of the tumorigenicity of src oncogenes.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Medical College of Pennsylvania, Philadelphia, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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