| pubmed-article:8570193 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8570193 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:8570193 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:8570193 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:8570193 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8570193 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8570193 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8570193 | pubmed:dateCreated | 1996-3-1 | lld:pubmed |
| pubmed-article:8570193 | pubmed:abstractText | We tested the hypothesis that wild-type p53 activity is required for c-Myc-dependent apoptosis in epithelial cells. Primary baby rat kidney epithelial cell lines were generated by immortalization through the concerted action of c-Myc and a temperature-sensitive (ts) dominant inhibitory mutant allele of p53 (BRK myc/p53ts cells). When shifted to the permissive temperature for wild-type p53 activity, the BRK myc/p53ts cells underwent growth arrest and apoptosis. However, apoptosis also could be induced by serum deprivation at the nonpermissive temperature, when p53 was in the mutant state. Bcl-2 suppressed both modes of cell death. Apoptosis induced by wild-type p53 but not by serum deprivation was accompanied by G1 cell cycle arrest and increased expression of the Bcl-2 antagonist Bax. We concluded that c-Myc could induce apoptosis in epithelial cells by at least two mechanisms that could be distinguished by their p53 requirement. Our results support the possibility that c-Myc-dependent cell death might be exploited for therapeutic ends during carcinoma development, without regard to p53 status of the target cell. | lld:pubmed |
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| pubmed-article:8570193 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8570193 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8570193 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8570193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8570193 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8570193 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8570193 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8570193 | pubmed:author | pubmed-author:WhiteEE | lld:pubmed |
| pubmed-article:8570193 | pubmed:author | pubmed-author:SakamuroDD | lld:pubmed |
| pubmed-article:8570193 | pubmed:author | pubmed-author:PrendergastG... | lld:pubmed |
| pubmed-article:8570193 | pubmed:author | pubmed-author:ShoweLL | lld:pubmed |
| pubmed-article:8570193 | pubmed:author | pubmed-author:ElliottK JKJ | lld:pubmed |
| pubmed-article:8570193 | pubmed:author | pubmed-author:EvinerVV | lld:pubmed |
| pubmed-article:8570193 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8570193 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:8570193 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:8570193 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8570193 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8570193 | pubmed:pagination | 2411-8 | lld:pubmed |
| pubmed-article:8570193 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8570193 | pubmed:meshHeading | pubmed-meshheading:8570193-... | lld:pubmed |
| pubmed-article:8570193 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8570193 | pubmed:articleTitle | c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms. | lld:pubmed |
| pubmed-article:8570193 | pubmed:affiliation | Wistar Institute, Philadelphia, Pennsylvania 19104, USA. | lld:pubmed |
| pubmed-article:8570193 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8570193 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8570193 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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