Linked Life Data

8569271

Source:http://linkedlifedata.com/resource/pubmed/id/8569271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-3-7
pubmed:abstractText
The hemodynamic effects of a single intravenous injection of doxorubicin (DXR) in a dose of 3 mg/kg, verapamil (Vp) in a dose of 0.2 mg/kg and combined administration of the same doses of both drugs in rabbits were investigated. Cardiac output (CO), stroke volume (SV), heart rate (HR), mean arterial pressure (MAP) and total peripheral resistance (TPR) were estimated before and repeated in the 1st, 15th, 30th, 45th, 60th, 90th and 120th minute after injection of the drugs. It was found that administration of Vp after DXR or DXR after Vp produced significant decrease of MAP. However, no significant changes of CO, SV, HR and TPR in rabbits treated with DXR and Vp were noted. Rhythm disturbances occurred in animals receiving DXR or DXR with Vp. The obtained results indicate the need for further experimental studies before the introduction of combined treatment with DXR and Vp to cancer patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-5246
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Does combined single intravenous injection of doxorubicin and verapamil have any influence on hemodynamic parameters in rabbits?
pubmed:affiliation
Department of Clinical Pharmacology, Medical University of Lód?, Poland.
pubmed:publicationType
Journal Article