Linked Life Data

8568775

Source:http://linkedlifedata.com/resource/pubmed/id/8568775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-3-6
pubmed:abstractText
The role of nitric oxide in the uterotrophic action of oestradiol after 6 h or 72 h was studied in immature (19-21 days old) female Wistar rats by use of L-arginine, the amino acid from which nitric oxide is synthesized, and N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Oestradiol at single s.c. doses of 2.5, 5.0 and 10.0 micrograms per rat induced dose-dependent uterine oedema in 6 h. L-NAME (10 and 20 mg kg-1, i.p.) administered 30 min before oestradiol (10 micrograms per rat) injection suppressed the formation of uterine oedema in a dose-related manner. This action of L-NAME on oestradiol-induced uterine oedema was effectively blocked by pretreatment of rats with L-arginine (600 mg kg-1, s.c.), a precursor of nitric oxide, but not by L-lysine, an amino acid not involved in the generation of nitric oxide. In addition, L-NAME at similar doses significantly prevented oestradiol-induced (3 micrograms per rat, s.c. on three successive days) increases in uterine growth after 72 h; however, this effect was mitigated by L-arginine (600 mg kg-1). These results suggest the involvement of an L-arginine-nitric oxide system in the oestradiol-induced uterotrophic effect in immature rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-4251
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Nitric oxide synthase inhibition and the uterotrophic response to oestrogen in immature rats.
pubmed:affiliation
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Ce, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't