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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0021013,
umls-concept:C0178539,
umls-concept:C0185117,
umls-concept:C0205369,
umls-concept:C0851285,
umls-concept:C1327616,
umls-concept:C1527178,
umls-concept:C1704689,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1979-6-11
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pubmed:abstractText |
An idiotype of the dinitrophenyl-binding myeloma protein MOPC 460 was expressed on a small but significant proportion of anti-TNP antibodies which appeared after in vivo or in vitro immunization of BALB/c mice with three T-independent TNP antigens. In vitro experiments show that the depletion of T cells before culture increased significantly the number of plaques secreting anti-TNP antibodies bearing MOPC 460 idiotype (460Id). T cells from BALB/c mice, but not from C.B20 mice, exhibit this suppressor activity. Plate-binding experiments indicate that the suppressive action of the T-lymphocyte population depends on a cell which can bind to MOPC 460 myeloma protein. The possible role of these normally occurring, idiotype-specific T cells on expression of 460Id in the anti-TNP antibody response of BALB/c mice is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-1082549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-1084404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-1089598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-1151286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-11993330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-270748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-303775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-325170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-417140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-4403565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-4541122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-4546826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-4623607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-5355110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-6059348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-75235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-99320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/85681-993595
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
592-600
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:85681-Animals,
pubmed-meshheading:85681-Antibodies, Anti-Idiotypic,
pubmed-meshheading:85681-Antibody Formation,
pubmed-meshheading:85681-Epitopes,
pubmed-meshheading:85681-Haptens,
pubmed-meshheading:85681-Immunity, Cellular,
pubmed-meshheading:85681-Immunoglobulin Idiotypes,
pubmed-meshheading:85681-Immunosuppression,
pubmed-meshheading:85681-Mice,
pubmed-meshheading:85681-Mice, Inbred Strains,
pubmed-meshheading:85681-Myeloma Proteins,
pubmed-meshheading:85681-T-Lymphocytes,
pubmed-meshheading:85681-Trinitrobenzenes
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pubmed:year |
1979
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pubmed:articleTitle |
Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype.
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pubmed:publicationType |
Journal Article
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