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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1996-3-1
pubmed:abstractText
We analyzed the role of Fyn tyrosine kinase in cell cycle progression of B lymphocyte progenitor (pro B cell). Whereas there were no substantial defects in the intramarrow B cell genesis in the fyn(-) mouse, and long-term proliferation of fyn(-) pro B cells was maintained in vitro under a serum containing culture condition, the cell cycle was arrested at G2/M upon serum deprivation. Morphological analyses demonstrated that the cytokinesis of fyn(-) pro B cells was retarded in the presence of serum and that the entry of fyn(-) pro B cells into late telophase was completely blocked under the serum-free condition. In contrast, the earlier phases of mitosis of fyn(-) pro B cells proceeded normally without FCS. This failure to initiate late telophase resulted in the accumulation of elliptical binucleated cells that might be the outcome of the nuclear division without cytokinesis. Consistent with this defect in the progression of cytokinesis, Fyn was localized in the midspace of dividing pro B cells at anaphase. These results suggested that Fyn localizes at the midspace of dividing pro B cells and regulates the progression of cytokinesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1361685, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1379736, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1387588, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1465444, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1516132, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1547487, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1608952, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1699949, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-1714601, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-2015626, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-2190221, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-2332734, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-2424020, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-3122025, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-3526330, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-379022, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-395133, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-4263445, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-5044763, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7509042, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7512695, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7513706, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7515933, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7517366, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7543134, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7612268, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7678277, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7680927, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7724579, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7799925, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7875200, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7962063, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7964471, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-7981151, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8262983, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8264796, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8315381, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8415665, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8476569, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8483935, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8489526, http://linkedlifedata.com/resource/pubmed/commentcorrection/8567733-8502471
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:8567733-Animals, pubmed-meshheading:8567733-B-Lymphocytes, pubmed-meshheading:8567733-Blotting, Western, pubmed-meshheading:8567733-Bone Marrow, pubmed-meshheading:8567733-Bone Marrow Cells, pubmed-meshheading:8567733-Cell Compartmentation, pubmed-meshheading:8567733-Cell Division, pubmed-meshheading:8567733-Culture Media, Serum-Free, pubmed-meshheading:8567733-Fluorescent Antibody Technique, pubmed-meshheading:8567733-Hematopoietic Stem Cells, pubmed-meshheading:8567733-Histocytochemistry, pubmed-meshheading:8567733-Mice, pubmed-meshheading:8567733-Mice, Inbred C57BL, pubmed-meshheading:8567733-Mice, Mutant Strains, pubmed-meshheading:8567733-Mitosis, pubmed-meshheading:8567733-Protein-Tyrosine Kinases, pubmed-meshheading:8567733-Proto-Oncogene Proteins, pubmed-meshheading:8567733-Proto-Oncogene Proteins c-fyn
pubmed:year
1996
pubmed:articleTitle
Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor.
pubmed:affiliation
Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan.
pubmed:publicationType
Journal Article
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