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rdf:type |
|
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1996-3-4
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pubmed:abstractText |
We investigated mutations of the epithelial (E)-cadherin gene and loss of heterozygosity (LOH) at flanking loci using three microsatellite markers on the long arm of chromosome 16 in 25 ductal carcinomas of the breast. Expression of E-cadherin was also investigated immunohistochemically. No mutations were detected in exons 6 through 9 of the E-cadherin gene. LOH was observed more frequently (42%) at D16S402 (16q-ter) than at D16S421 (16q22.3-q23.1) (17%), which is located near the E-cadherin gene. Expression of E-cadherin was observed at the cell borders in 92% (11/12) of the tumors examined. The absence of mutations in the E-cadherin gene and its conserved expression suggest that inactivation of E-cadherin does not contribute significantly to the invasion or metastatic potential of ductal carcinomas of the breast. Furthermore, the high frequency of LOH at 16q-ter suggests the existence of another tumor suppressor gene which may play a crucial role in the genesis of ductal carcinomas of the breast.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0910-5050
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1054-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8567396-Adenocarcinoma, Scirrhous,
pubmed-meshheading:8567396-Aneuploidy,
pubmed-meshheading:8567396-Base Sequence,
pubmed-meshheading:8567396-Breast Neoplasms,
pubmed-meshheading:8567396-Cadherins,
pubmed-meshheading:8567396-Carcinoma, Ductal, Breast,
pubmed-meshheading:8567396-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:8567396-Cell Adhesion,
pubmed-meshheading:8567396-DNA, Neoplasm,
pubmed-meshheading:8567396-DNA, Satellite,
pubmed-meshheading:8567396-Humans,
pubmed-meshheading:8567396-Molecular Sequence Data,
pubmed-meshheading:8567396-Neoplasm Invasiveness,
pubmed-meshheading:8567396-Neoplasm Proteins,
pubmed-meshheading:8567396-Polymerase Chain Reaction,
pubmed-meshheading:8567396-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:8567396-Receptors, Estrogen
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pubmed:year |
1995
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|
pubmed:articleTitle |
Epithelial-cadherin gene is not mutated in ductal carcinomas of the breast.
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pubmed:affiliation |
Department of Pathology, School of Medicine, Iwate Medical University, Morioka.
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pubmed:publicationType |
Journal Article,
Comparative Study
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