|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1996-3-1
|
|
pubmed:abstractText |
Experimental infection of mice with the intracellular bacterium, Listeria monocytogenes, provides a paragon model for immune defence dominated by T helper type 1 (Th1) responses. Potent production of interleukin (IL)-12 by infected macrophages is considered the determining factor in Th1 cell development. In contrast, it is assumed that IL-4 producers remain virtually unstimulated in listeriosis. In the liver, the major target organ of listeriosis, an unusual T lymphocyte population exists with the intriguing phenotype CD4+ NK1.1+ TCR alpha/beta intermediate (TCR alpha/beta int). Here we show that IL-4-producing CD4+ NK1.1+ TCR alpha/beta int liver lymphocytes are down-regulated early in listeriosis. We assume that curtailment of IL-4-producing CD4+ NK1.1+ TCR alpha/beta int liver lymphocytes promotes unconstrained development of Th1 cells which are central to protection against intracellular bacteria.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Klrb1c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
25
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3321-5
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8566018-Animals,
pubmed-meshheading:8566018-Antigens,
pubmed-meshheading:8566018-Antigens, Ly,
pubmed-meshheading:8566018-Antigens, Surface,
pubmed-meshheading:8566018-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8566018-Cytokines,
pubmed-meshheading:8566018-Down-Regulation,
pubmed-meshheading:8566018-Female,
pubmed-meshheading:8566018-Interleukin-4,
pubmed-meshheading:8566018-Lectins, C-Type,
pubmed-meshheading:8566018-Listeria monocytogenes,
pubmed-meshheading:8566018-Listeriosis,
pubmed-meshheading:8566018-Liver,
pubmed-meshheading:8566018-Lymphocyte Subsets,
pubmed-meshheading:8566018-Male,
pubmed-meshheading:8566018-Mice,
pubmed-meshheading:8566018-Mice, Inbred C57BL,
pubmed-meshheading:8566018-Mice, Mutant Strains,
pubmed-meshheading:8566018-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:8566018-Proteins,
pubmed-meshheading:8566018-Receptors, Antigen, T-Cell, alpha-beta
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Interleukin-4-producing CD4+ NK1.1+ TCR alpha/beta intermediate liver lymphocytes are down-regulated by Listeria monocytogenes.
|
|
pubmed:affiliation |
Department of Immunology, University of Ulm, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
