Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1977-6-22
pubmed:abstractText
Metabolic balance and calcium kinetic studies were performed in four patients with Paget's disease before treatment with salmon calcitonin and during the early and late stages of the treatment, which lasted 9 to 19 months, A significant decrease in bone turnover and 24-hour urine hydroxyproline and serum alkaline phosphatase values was observed in all patients. In contrast, the calcium, phosphorus and magnesium balances did not change significantly. In agreement with this, the partial body calcium, measured by in vivo neutron activation analysis, did not change. Intestinal calcium absorption increased initially, but returned to baseline levels 9 to 19 months after the study began. During the initial period there was a small, significant, but transient decrease in tubular reabsorption of phosphorus; this was accompanied by a significant decrease in serum phosphorus values--probably a direct effect of calcitonin rather than evidence of secondary hyperparathyroidism. Administration of salmon calcitonin to patients with Paget's disease decreases bone turnover without affecting calcium and phosphorus balances.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-1110417, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-1128238, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-14168917, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4102856, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4180609, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4198020, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4351164, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4472557, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4697821, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4798239, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4916538, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-4935444, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-5460839, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-5464079, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-5808450, http://linkedlifedata.com/resource/pubmed/commentcorrection/856428-6048697
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0008-4409
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
851-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Metabolic balance studies in patients with Paget's disease receiving salmon calcitonin over long periods.
pubmed:publicationType
Journal Article