Linked Life Data

8562887

Source:http://linkedlifedata.com/resource/pubmed/id/8562887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-3-1
pubmed:abstractText
The effect of a three-week treatment regimen with 2, 4 or 6 mg aurintricarboxylic acid (ATA) per kg body weight on the cell proliferation of jejunal crypts and dorsal epidermis of the nude mouse was studied using standard autoradiographic methods after in vivo pulse labelling with 3H-thymidine. ATA was slightly toxic to the animals in a dose-dependent manner (p < 0.01), as measured by the decrease of the rate of weight gain of the treated animals. In the small intestine, ATA led to a shrinkage of crypt length by a factor of 10-15% (p < 0.05), mainly by inhibiting cell proliferation in a dose-dependent manner (p < 0.05) and only secondarily and at higher doses by additionally increasing the cell loss. On the contrary, both the 3H-thymidine labelling index and the mitotic index of the basal cell layer of the epidermis are found to be increased under treatment with ATA. Thus, the present findings indicate that ATA may differentially affect the tissue homeostasis of different renewable epithelia in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0258-851X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-23
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Studies on the effect of aurintricarboxylic acid (ATA) on cell proliferation of renewable epithelial tissues in the mouse.
pubmed:affiliation
Institute of Medical Radiation and Cell Research (MSZ), University of Würzburg, Germany.
pubmed:publicationType
Journal Article