Linked Life Data

8562656

Source:http://linkedlifedata.com/resource/pubmed/id/8562656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-3-1
pubmed:abstractText
Earlier it has been demonstrated that the recoupling action of cyclosporin A on mitochondria deenergized by the opening of the Ca(+)-dependent pore requires higher cyclosporin A concentrations than those, which are necessary for preventing the permeabilization as well as the presence of additional effectors, such as adenine nucleotides and Mg2+. It has been shown that cyclosporin A reseals the pore and prevents its opening when used at the same low concentrations (0.1-0.4 microM), while its higher concentrations (0.5-1.0 microM) produce the recoupling of mitochondria. In contrast with recoupling, resealing of the pore by cyclosporin A does not require Mg2+ or adenine nucleotides. Carboxyatractylate which reverses the cyclosporin A-induced restoration of the membrane potential does not induce repeated opening of the pore. The carboxyatractylate-induced depolarization of the inner mitochondrial membrane is sensitive to ruthenium red. Besides, ruthenium red restores the recoupling action of cyclosporin A in the absence of carboxyatractylate. The data obtained suggest that the loss by cyclosporin A of its recoupling potency may result from the induction of the Ca2+/2H+ antiporter. Induction of the Ca2+/2H+ antiporter in combination with a ruthenium red-sensitive Ca2+ uniporter provides the uncoupling mitochondria even with a closed Ca(2+)-dependent pore. Apparently, Ca2+/2H+ antiporter induction is a result of inhibition of the ADP/ATP antiporter by a natural or exogenous inhibitor. This process seems to require a preliminary release of certain protective factors from the mitochondrial matrix.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1502-11
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Low concentrations of cyclosporin A close Ca2+-dependent inner mitochondrial membrane pores in the absence of other effectors].
pubmed:publicationType
Journal Article, English Abstract