Linked Life Data

8561458

Source:http://linkedlifedata.com/resource/pubmed/id/8561458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-2-27
pubmed:abstractText
The protozoan parasite Trypanosoma cruzi must enter cells of its vertebrate host in order to replicate. Once this is accomplished, the infective trypomastigotes can invade many different cell types from several host species. This observation is in agreement with the parasite's wide natural host range. Studies performed with cultured mammalian cells in vitro have shown that T. cruzi invasion is an unusual process, distinct from phagocytosis, that depends on parasite energy and on negatively charged surface molecules of the host cell. Several surface glycoproteins and mucin-like molecules of trypomastigotes have been implicated, mainly by inhibition studies with antibodies, in interactions with host cells. Recently, several of the trypomastigote surface glycoproteins were shown to be related members of a large family that includes the T. cruzi trans-sialidase. The mucin-like molecules are beginning to emerge as a separate family of threonine-rich, O-glycosylated molecules that function as acceptors of sialic acid in the infective stages. Several lines of evidence suggest that parasite surface molecules mediate binding to host cells, whereas invasion of nonphagocytic cells involves recruitment of host-cell lysosomes, an unusual event apparently triggered by signal transduction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0066-4227
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-200
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The mechanisms of Trypanosoma cruzi invasion of mammalian cells.
pubmed:affiliation
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't