Linked Life Data

8558942

Source:http://linkedlifedata.com/resource/pubmed/id/8558942

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-2-26
pubmed:abstractText
The MLL gene, located at chromosome 11, band q23, is frequently disrupted by a variety of chromosomal rearrangements that occur in acute lymphoblastic leukemias and in a subset of de novo and secondary acute myeloid leukemias. In both scenarios, MLL rearrangements are associated with distinct clinical features and a poor prognosis. MLL encodes a large protein (MLL) that shares homology with the Drosophila trithorax protein. 11q23 translocations result in the generation of a series of acute leukemia-specific chimeric proteins that contain the N-terminus of MLL and are thought to be crucial to leukemogenesis. In this article, we review the structural features of the MLL fusion proteins as well as the clinical features and molecular diagnosis of acute leukemias containing MLL arrangements.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-82
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
11q23 rearrangements in acute leukemia.
pubmed:affiliation
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't