rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017968,
umls-concept:C0024264,
umls-concept:C0028959,
umls-concept:C0036920,
umls-concept:C0175630,
umls-concept:C0205282,
umls-concept:C0206243,
umls-concept:C0330390,
umls-concept:C0441889,
umls-concept:C1171362,
umls-concept:C1515670
|
pubmed:issue |
1
|
pubmed:dateCreated |
1996-2-26
|
pubmed:abstractText |
The circulating forms of malignant cells from patients with Sezary syndrome exhibit on their glycoproteins a high level of beta (1-6)GlcNAc-branched N-linked oligosaccharides, a particular species of glycans related to the metastatic potential of several tumors and T lymphocytes activation. An increased activity of the N-acetylglucosaminyltransferase V and of the beta (1-4)galactosyltransferase, two enzymes implicated in beta (1-6)GlcNAc-branching is also found. Nevertheless, contrary to activated normal T lymphocytes, Sezary lymphocytes in agreement with their non-proliferating state, do not exhibit increased thymidine uptake. This result suggests that expression of the beta (1-6)GlcNAc-branched N-linked carbohydrates could be related to some of the malignant properties of Sezary lymphocytes.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0887-6924
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
138-41
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8558919-Acetylglucosamine,
pubmed-meshheading:8558919-Female,
pubmed-meshheading:8558919-Glycoproteins,
pubmed-meshheading:8558919-Humans,
pubmed-meshheading:8558919-Lymphocyte Activation,
pubmed-meshheading:8558919-Lymphocytes,
pubmed-meshheading:8558919-Male,
pubmed-meshheading:8558919-Middle Aged,
pubmed-meshheading:8558919-N-Acetylglucosaminyltransferases,
pubmed-meshheading:8558919-Oligosaccharides,
pubmed-meshheading:8558919-Sezary Syndrome,
pubmed-meshheading:8558919-Skin Neoplasms,
pubmed-meshheading:8558919-T-Lymphocytes,
pubmed-meshheading:8558919-beta-N-Acetylglucosaminylglycopeptide...
|
pubmed:year |
1996
|
pubmed:articleTitle |
Circulating malignant lymphocytes from Sezary syndrome express high level of glycoproteins carrying beta (1-6)N-acetylglucosamine-branched N-linked oligosaccharides.
|
pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale U 180, Université Paris-V René Descartes, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|