| pubmed-article:8557757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0070099 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0332255 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C1150572 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0135520 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:8557757 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8557757 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8557757 | pubmed:dateCreated | 1996-2-26 | lld:pubmed |
| pubmed-article:8557757 | pubmed:abstractText | Low concentrations of the C-terminal parathyroid hormone-related protein (PTHrP) fragments, PTHrP-(107-111) and PTHrP-(107-139), stimulated membrane-associated protein kinase Cs (PKCs), but not adenylyl cyclase or an internal Ca2+ surge, in early passage human skin keratinocytes and BALB/MK-2 murine skin keratinocytes. The fragment maximally stimulated membrane-associated PKCs in BALB/MK-2 cells at 5 x 10(-9) to 10(-8) M. The maximally PKC-stimulating concentrations of PTHrP-(107-111) also stopped or stimulated BALB/MK-2 keratinocyte proliferation depending on whether the cells were, respectively, cycling or quiescent at the time of exposure. Thus, just one brief (30-minute) pulse of 10(-8) M PTHrP-(107-111) stopped the proliferation of BALB/MK-2 keratinocytes for at least 5 days. On the other hand, daily 30-minute pulses of 10(-8) M PTHrP-(107-111) started and then maintained the proliferation of initially quiescent BALB/MK-2 cells. Similarly PTHrP-(107-111) inhibited DNA synthesis by cycling primary adult human keratinocytes, but it stimulated DNA synthesis by quiescent human keratinocytes. | lld:pubmed |
| pubmed-article:8557757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8557757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557757 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8557757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8557757 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8557757 | pubmed:issn | 0021-9541 | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:BarisoniDD | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:WhitfieldJ... | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:IsaacsR JRJ | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:ArmatoUU | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:MorleyPP | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:ChakravarthyB... | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:JouishommeHH | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:RegaliaEE | lld:pubmed |
| pubmed-article:8557757 | pubmed:author | pubmed-author:MacLeanSS | lld:pubmed |
| pubmed-article:8557757 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8557757 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:8557757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8557757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8557757 | pubmed:pagination | 1-11 | lld:pubmed |
| pubmed-article:8557757 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8557757 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8557757 | pubmed:articleTitle | C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes. | lld:pubmed |
| pubmed-article:8557757 | pubmed:affiliation | Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada. | lld:pubmed |
| pubmed-article:8557757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8557757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8557757 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8557757 | lld:pubmed |
