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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1996-2-28
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pubmed:abstractText |
Bacillomycin Lc, a new antifungal antibiotic of the iturin class, was isolated from a strain of Bacillus subtilis as a set of five congeners. The structure as determined by chemical and spectrometric analyses has been shown to differ from that of bacillomycin L by sequence changes from aspartate-1 to asparagine-1 and from glutamine-5 to glutamate-5. The five congeners differ from each other only in the structure of the aliphatic side chain of the constituent beta-amino acid. The hydrophobicity of the beta-amino acid affects the antifungal activity of the congener, as activity increased in the order of increased congener retention on a reversed-phase HPLC column.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-8820
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1240-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8557563-Amino Acid Sequence,
pubmed-meshheading:8557563-Amino Acids,
pubmed-meshheading:8557563-Antifungal Agents,
pubmed-meshheading:8557563-Bacillus subtilis,
pubmed-meshheading:8557563-Chemistry, Physical,
pubmed-meshheading:8557563-Chromatography, High Pressure Liquid,
pubmed-meshheading:8557563-Fungi,
pubmed-meshheading:8557563-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8557563-Molecular Sequence Data,
pubmed-meshheading:8557563-Molecular Structure,
pubmed-meshheading:8557563-Peptides, Cyclic,
pubmed-meshheading:8557563-Physicochemical Phenomena,
pubmed-meshheading:8557563-Sequence Analysis,
pubmed-meshheading:8557563-Spectrometry, Mass, Fast Atom Bombardment
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pubmed:year |
1995
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pubmed:articleTitle |
Bacillomycin Lc, a new antibiotic of the iturin group: isolations, structures, and antifungal activities of the congeners.
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pubmed:affiliation |
USDA Forest Service, Forestry Sciences Laboratory, Delaware, OH 43015, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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