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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1996-2-27
|
| pubmed:abstractText |
This study examines the role of uraemia and the effect of different dialysis treatments on red cell cation transport. We evaluated the main cation transport systems in erythrocytes of non-dialysed end-stage renal disease (ESRD) subjects, of patients undergoing haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD), as well as the changes induced by human recombinant erythropoietin (r-HuEPO) administration. In uraemic undialysed and dialysed patients, we observed an increase in K/Cl co-transport activity and in shrinkage-induced amiloride-sensitive (HMA-sensitive) Na efflux (Na/H exchange) and a decrease in Na/K pump and Na/K/Cl co-transport activity, while Na/Li exchange was increased only in dialysed patients. In uraemic erythrocytes, we showed for the first time an increased K/Cl co-transport activity, which was cell age independent. Generally, the different method of dialysis (CAPD or HD) did not modify the cation transport abnormalities observed. During the treatment with r-HuEPO, all the systems, with the exception of the Na/K pump and Na/K/Cl co-transport, increased their activities following the increase of circulating young red cells. The changes produced under r-HuEPO administration were transient and cation transports returned to the baseline values within 100 days of treatment, indicating a primary and prominent pathogenetic role of uraemia in modulating the red cell membrane cation transport activities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2972
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
762-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8557063-Anemia,
pubmed-meshheading:8557063-Chlorides,
pubmed-meshheading:8557063-Erythrocytes,
pubmed-meshheading:8557063-Erythropoietin,
pubmed-meshheading:8557063-Humans,
pubmed-meshheading:8557063-Ion Transport,
pubmed-meshheading:8557063-Kidney Failure, Chronic,
pubmed-meshheading:8557063-Peritoneal Dialysis, Continuous Ambulatory,
pubmed-meshheading:8557063-Potassium,
pubmed-meshheading:8557063-Renal Dialysis,
pubmed-meshheading:8557063-Renal Replacement Therapy,
pubmed-meshheading:8557063-Sodium,
pubmed-meshheading:8557063-Uremia
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Red blood cell cation transports in uraemic anaemia: evidence for an increased K/Cl co-transport activity. Effects of dialysis and erythropoietin treatment.
|
| pubmed:affiliation |
Department of Internal Medicine, University of Verona, Italy.
|
| pubmed:publicationType |
Journal Article
|