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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1996-2-23
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pubmed:abstractText |
Hypothermia prolongs the time-course of action of non-depolarizing neuromuscular blocking agents. The mechanism, however, is unknown. We studied the influence of hypothermia (by surface cooling, nasopharyngeal temperature < or = 31 degrees C) on the time-course of action and on the pharmacokinetics of rocuronium in humans. Nineteen neurosurgical patients were divided into hypothermic and normothermic groups. Hypothermia (30.4 +/- 0.8 degrees C (mean +/- SD)) increased the duration of action, temperature dependently, and delayed the recovery. Hypothermia reduced the plasma clearance significantly (2.17 +/- 0.62 vs. 4.26 +/- 0.50 mL kg-1 min-1, P = 0.004), did not change the volume of distribution (224 +/- 64 vs. 232 +/- 60 mL kg-1 min-1, P = 1.0), and prolonged the mean residence time (108 +/- 39 vs. 56 +/- 19 mL kg-1 min-1, P = 0.01). We conclude that hypothermia prolongs the duration of action of rocuronium and delays spontaneous recovery and that altered pharmacokinetics, such as a decreased clearance, play an important role in this.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0952-1941
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-106
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pubmed:dateRevised |
2007-5-23
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pubmed:meshHeading |
pubmed-meshheading:8557016-Androstanols,
pubmed-meshheading:8557016-Anesthesia,
pubmed-meshheading:8557016-Female,
pubmed-meshheading:8557016-Humans,
pubmed-meshheading:8557016-Hypothermia, Induced,
pubmed-meshheading:8557016-Intracranial Aneurysm,
pubmed-meshheading:8557016-Male,
pubmed-meshheading:8557016-Middle Aged,
pubmed-meshheading:8557016-Muscle Contraction,
pubmed-meshheading:8557016-Neuromuscular Nondepolarizing Agents
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pubmed:year |
1995
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pubmed:articleTitle |
The influence of hypothermia (surface cooling) on the time-course of action and on the pharmacokinetics of rocuronium in humans.
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pubmed:affiliation |
Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
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