Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-2-23
|
| pubmed:abstractText |
Patients infected with human immunodeficiency virus (HIV) are at risk for a variety of liver diseases. We undertook a retrospective study of 501 HIV-seropositive patients to assess the yield of percutaneous liver biopsy. The most common indications for liver biopsy were liver test abnormalities (89.5%), fever for 2 weeks (71.9%), and hepatomegaly (52.0%). The most common biopsy-derived diagnosis was Mycobacterium avium complex (MAC), seen in 87 (17.4%) biopsies. Mycobacterium tuberculosis was found in 13 biopsies (2.6%). In 28 biopsies (5.6%) mycobacteria was seen, but speciation of the organism was not possible. Chronic active viral hepatitis was seen in 60 biopsies (12.0%). Opportunistic hepatic infection from other organisms was found in 14 biopsies (2.8%). The most common neoplasm was lymphoma, which was seen in 12 biopsies (2.4%). MAC infection of the liver was associated with elevated alkaline phosphatase (p = 0.01). Among patients with fever for 2 weeks after an extensive negative workup including bone marrow biopsy, 58.2% had a diagnosis by liver biopsy. Overall, 64.3% of liver biopsies yielded a histopathological diagnosis, 45.7% of which were potentially treatable. We could not evaluate whether liver biopsy had a positive effect on patient outcome and survival, nor did we attempt to prove that liver biopsy resulted in a change in treatment or a change in preprocedure clinical diagnosis. Thus, questions about the efficacy of liver biopsy cannot be answered. Liver biopsy may be a helpful diagnostic tool in HIV-positive patients with fever, liver test abnormalities or hepatomegaly.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1077-9450
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
170-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8556399-Adolescent,
pubmed-meshheading:8556399-Adult,
pubmed-meshheading:8556399-Aged,
pubmed-meshheading:8556399-Biopsy, Needle,
pubmed-meshheading:8556399-CD4 Lymphocyte Count,
pubmed-meshheading:8556399-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8556399-Child,
pubmed-meshheading:8556399-Child, Preschool,
pubmed-meshheading:8556399-Female,
pubmed-meshheading:8556399-HIV Infections,
pubmed-meshheading:8556399-HIV Seropositivity,
pubmed-meshheading:8556399-HIV-1,
pubmed-meshheading:8556399-Hepatomegaly,
pubmed-meshheading:8556399-Humans,
pubmed-meshheading:8556399-Infant,
pubmed-meshheading:8556399-Liver,
pubmed-meshheading:8556399-Liver Diseases,
pubmed-meshheading:8556399-Liver Function Tests,
pubmed-meshheading:8556399-Male,
pubmed-meshheading:8556399-Middle Aged,
pubmed-meshheading:8556399-Retrospective Studies
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Liver biopsy findings in 501 patients infected with human immunodeficiency virus (HIV).
|
| pubmed:affiliation |
New York University Medical Center, NY 10016, USA.
|
| pubmed:publicationType |
Journal Article
|