Linked Life Data

8555981

Source:http://linkedlifedata.com/resource/pubmed/id/8555981

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-2-27
pubmed:abstractText
In this study we compared the performance of male Wistar rats, weighing 250-300 g, submitted to the standard plus maze (vertical surfaces of the closed arms with opaque walls) to their performance in a modified maze with raised Plexiglas edges in the closed arms (transparent walls). The animals (N = 12 for each group) continued to show a clear preference for the closed arms with transparent walls of the modified elevated plus maze. In addition, exploratory activity was higher in the open arms of the modified plus maze (4.25 +/- 0.42 entries and 53.50 +/- 5.10 s) as compared to that of the standard plus maze (2.10 +/- 0.25 entries and 24.00 +/- 4.91 s). Intraperitoneal injection of midazolam produced an increase in the number of entries (6.40 +/- 1.21 and 8.50 +/- 1.15 for 1.0 and 2.0 mg/kg, respectively) and in the time spend in the open arms (85.32 +/- 14.56 and 125.50 +/- 22.16 s for 1.0 and 2.0 mg/kg, respectively) while pentylenetetrazole caused a decrease in the number of entries (3.68 +/- 0.54 and 2.33 +/- 0.62 for 5.0 and 10 mg/kg, respectively) and in the time spent in the open arms of the modified maze (39.60 +/- 6.67 and 23.60 +/- 6.40 s for 5.0 and 10 mg/kg, respectively). The anxiolytic effect of midazolam and the anxiogenic effect of pentylenetetrazole were similar to those usually reported in the literature by authors using the standard test. These results behaviorally and pharmacologically validate the elevated plus maze with transparent walls and suggest that this test could be a useful tool for the study of anxiolytic drugs and the neurobiology of anxiety.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
597-601
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Behavioral and pharmacological validation of the elevated plus maze constructed with transparent walls.
pubmed:affiliation
Laboratório de Psicobiologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Brasil.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't