Linked Life Data

8554985

Source:http://linkedlifedata.com/resource/pubmed/id/8554985

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pubmed-article:8554985pubmed:abstractTextNuclear magnetic resonance (NMR) non-invasively measures the apparent diffusion coefficient (ADC) of water, which is sensitive to the biophysical characteristics of tissue. Because anti-cancer treatment alters tumour pathophysiology, tumour ADC may be altered by treatment. In order to test this hypothesis, ADC was measured in s.c. implanted murine RIF-1 tumours before and up to 9 days after treatment with cyclophosphamide. A dose-dependent, reversible increase in tumour ADC was observed after cyclophosphamide treatment, which is consistent with an increase in the fraction of interstitial water due to treatment-induced cell death. Because tumour water ADC is increased substantially at a time when there is no change in tumour volume for a dose which produces minimal cell kill, its measurement could provide a novel means for early detection of response to anti-cancer therapy. If the changes in ADC observed in the present study are evident for commonly used anti-cancer therapies in different tumour types and specific to a therapeutic response, the approach could be broadly applicable as a response predictor since magnetic resonance imaging can be used to measure ADC in human tumours.lld:pubmed
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pubmed-article:8554985pubmed:articleTitleEarly detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo.lld:pubmed
pubmed-article:8554985pubmed:affiliationDepartment of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.lld:pubmed
pubmed-article:8554985pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8554985pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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