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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-2-26
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pubmed:abstractText |
Nuclear magnetic resonance (NMR) non-invasively measures the apparent diffusion coefficient (ADC) of water, which is sensitive to the biophysical characteristics of tissue. Because anti-cancer treatment alters tumour pathophysiology, tumour ADC may be altered by treatment. In order to test this hypothesis, ADC was measured in s.c. implanted murine RIF-1 tumours before and up to 9 days after treatment with cyclophosphamide. A dose-dependent, reversible increase in tumour ADC was observed after cyclophosphamide treatment, which is consistent with an increase in the fraction of interstitial water due to treatment-induced cell death. Because tumour water ADC is increased substantially at a time when there is no change in tumour volume for a dose which produces minimal cell kill, its measurement could provide a novel means for early detection of response to anti-cancer therapy. If the changes in ADC observed in the present study are evident for commonly used anti-cancer therapies in different tumour types and specific to a therapeutic response, the approach could be broadly applicable as a response predictor since magnetic resonance imaging can be used to measure ADC in human tumours.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-136109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-1513459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-1880564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-1995535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-2175008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-2345513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-3118123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-3390814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-3763909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-4823458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-6928244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-7726086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-7909867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-7968441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-8056579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-8108392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-8229124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-8259418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8554985-8366805
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8554985-Animals,
pubmed-meshheading:8554985-Antineoplastic Agents, Alkylating,
pubmed-meshheading:8554985-Cell Membrane Permeability,
pubmed-meshheading:8554985-Cyclophosphamide,
pubmed-meshheading:8554985-Diffusion,
pubmed-meshheading:8554985-Dose-Response Relationship, Drug,
pubmed-meshheading:8554985-Female,
pubmed-meshheading:8554985-Fibrosarcoma,
pubmed-meshheading:8554985-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8554985-Mice,
pubmed-meshheading:8554985-Mice, Inbred C3H,
pubmed-meshheading:8554985-Neoplasm Transplantation,
pubmed-meshheading:8554985-Neoplasms, Radiation-Induced,
pubmed-meshheading:8554985-Protons,
pubmed-meshheading:8554985-Water
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pubmed:year |
1996
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pubmed:articleTitle |
Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo.
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pubmed:affiliation |
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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