Linked Life Data

8554914

Source:http://linkedlifedata.com/resource/pubmed/id/8554914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-2-27
pubmed:databankReference
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1143-5
pubmed:dateRevised
2009-11-19
pubmed:otherAbstract
PIP: Findings are reported from a study conducted to fully sequence the gp120 gene from a Brazilian HIV-1 isolate containing the GWGR motif and compare it to the Brazilian B and F sequences already described. Genomic DNA isolated from six patients in an ongoing HIV cohort study was screened for the presence of the viral V3 loop GWGR motif. Sequence analysis revealed that BZ(GWGR)1 is closely related to the North American MN prototype strain, with 80.1% amino acid identity and 89.1% nucleic acid similarity, and with 6 deletions and 11 insertions. Large differences were, however, observed when the V1 and V2 regions of MN and BZ(GWGR)1 were compared. Tree analysis based upon amino acid sequences and the four Brazilian isolates introduced in the analysis indicate that BZ(GWGR)1 belongs to the HIV-1 B subtypes. Several features of BZ(GWGR)1 suggest that some biological advantage may be derived from the differences between that variant and the American/European prototype strain.
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Sequence and phylogenetic analysis of glycoprotein 120 of an HIV type 1 variant (GWGR) prevalent in Brazil.
pubmed:affiliation
Departamento de Genética, Universidade Federal do Rio de Janeiro, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't