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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-2-22
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pubmed:abstractText |
We investigated whether lipoteichoic acid (LTA) induces the expression of E-selectin and neutrophil adhesion to human umbilical vein endothelial cells (HUVECs). LTA (0.01-30 micrograms/ml) induced the expression of E-selectin in a concentration-dependent manner with maximal response at 10 micrograms/ml. The expression level of E-selectin increased from 2 h after stimulation by LTA with the maximal level at 4-8 h. Neutrophil adhesion to LTA-treated HUVECs correlated with the levels of E-selectin expression. In addition, the adhesion was clearly inhibited by anti-human E-selectin monoclonal antibody CY-1787 as well as a sialyl Lewis X (SLeX) oligosaccharide. LTA-induced expression of E-selectin was inhibited by protein kinase C inhibitors, H-7 and staurosporine. These results indicate that LTA induced the expression of E-selectin and neutrophils adhered to HUVECs via E-selectin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
217
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1208-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8554578-Cell Adhesion,
pubmed-meshheading:8554578-Cells, Cultured,
pubmed-meshheading:8554578-E-Selectin,
pubmed-meshheading:8554578-Endothelium, Vascular,
pubmed-meshheading:8554578-Humans,
pubmed-meshheading:8554578-Intercellular Adhesion Molecule-1,
pubmed-meshheading:8554578-Lipopolysaccharides,
pubmed-meshheading:8554578-Neutrophils,
pubmed-meshheading:8554578-Polysaccharides, Bacterial,
pubmed-meshheading:8554578-Protein Kinase C,
pubmed-meshheading:8554578-Teichoic Acids,
pubmed-meshheading:8554578-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1995
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pubmed:articleTitle |
Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs).
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pubmed:affiliation |
Sumitomo Pharmaceuticals, Research Center, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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