Linked Life Data

8554576

Source:http://linkedlifedata.com/resource/pubmed/id/8554576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-2-22
pubmed:abstractText
In piglets studied on the first day of life transient hypoxia-ischaemia caused an increase in the fractions of necrotic and apoptotic cells in the cingulate sulcus compared to sham-operated controls. In animals subjected to the same hypoxic-ischaemic insult but cooled to 34.9 degrees C (mean tympanic membrane temperature) for 12 hours commencing after resuscitation the fraction of cells undergoing necrosis was unchanged and comparable to that in animals which were not cooled. However, the fraction of apoptotic cells was reduced and was similar to that in sham-operated controls. Thus hypothermia specifically inhibited apoptosis. This result has implications for understanding the mechanisms of delayed cerebral injury and for the use of hypothermia as a neural rescue strategy in the developing brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1193-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia.
pubmed:affiliation
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London, UK.
pubmed:publicationType
Journal Article