Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1996-2-22
|
| pubmed:abstractText |
From October 1988 to July 1990, 18 patients with marginally resectable non-small cell cancer (10 stage IIIa and 8 stage IIIb) were entered in a phase-II trial combining induction therapy with a subsequent thoracotomy. Induction therapy included 2 courses of chemotherapy (5-FU and cisplatinum) and radiotherapy (30 Gray in split course). Partial response was observed in 10 patients, and minimal response in 3. Thoracotomy disclosed unresectability in 3 patients. Fifteen complete resections consisted in 1 lobectomy and 14 pneumonectomies. There were no operative deaths (30 days). Postoperative recovery was uneventful in 3 patients with exploratory thoracotomy and in 1 patient with lobectomy. Following pneumonectomy, we observed 2 bronchopleural fistulae and 1 empyema. On pathology, 10 patients were stage IIIa, and 3 were stage I, whereas no residual tumor was found in 2 patients. During follow-up, local recurrence occurred in 2, and metastases in 8. On December 31st, 1993, 3 patients were alive at 44, 52, and 62 months respectively. Nine patients had died from cancer, and 3 from unrelated causes. Estimated survival was 66.7% at 1 year, 33.3% at 3 years, and 20% at 5 years. We conclude that induction therapy allowed satisfactory resection for marginally resectable tumors. Operative morbidity was increased in this group. However, the 5-year survival was similar to resectable stage IIIa cancer.
|
| pubmed:language |
fre
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0003-3944
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
841-8
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading |
pubmed-meshheading:8554283-Adult,
pubmed-meshheading:8554283-Aged,
pubmed-meshheading:8554283-Antimetabolites, Antineoplastic,
pubmed-meshheading:8554283-Antineoplastic Agents,
pubmed-meshheading:8554283-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8554283-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:8554283-Cisplatin,
pubmed-meshheading:8554283-Combined Modality Therapy,
pubmed-meshheading:8554283-Female,
pubmed-meshheading:8554283-Fluorouracil,
pubmed-meshheading:8554283-Follow-Up Studies,
pubmed-meshheading:8554283-Humans,
pubmed-meshheading:8554283-Lung Neoplasms,
pubmed-meshheading:8554283-Male,
pubmed-meshheading:8554283-Middle Aged,
pubmed-meshheading:8554283-Postoperative Complications,
pubmed-meshheading:8554283-Preoperative Care,
pubmed-meshheading:8554283-Radiotherapy Dosage
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
[Contribution of an induction treatment in the surgical treatment of locally advanced non-small-cell cancers].
|
| pubmed:affiliation |
Service de Chirurgie Thoracique, Hôpitaux Universitaires de Strasbourg.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|