Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-2-22
pubmed:databankReference
pubmed:abstractText
Due to the resurgence of tuberculosis and the emergence of multidrug-resistant strains, fluoroquinolones (FQ) are being used in selected tuberculosis patients, but FQ-resistant strains of Mycobacterium tuberculosis have rapidly begun to appear. The mechanisms involved in FQ resistance need to be elucidated if the effectiveness of this class of antibiotics is to be improved and prolonged. By using the rapid-growing Mycobacterium smegmatis as a model genetic system, a gene was selected that confers low-level FQ resistance when present on a multicopy plasmid. This gene, lfrA, encodes a putative membrane efflux pump of the major facilitator family, which appears to recognize the hydrophilic FQ, ethidium bromide, acridine, and some quaternary ammonium compounds. It is homologous to qacA from Staphylococcus aureus, tcmA, of Streptomyces glaucescens, and actII and mmr, both from Streptomyces coelicoler. Increased expression of lfrA augments the appearance of subsequent mutations to higher-level FQ resistance.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1330320, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1334483, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1409590, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1503431, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1549509, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1616212, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1656869, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1658570, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1675788, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1851537, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1878971, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1904554, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1987461, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-1992885, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-2089219, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-2127272, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-2174864, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-2231712, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-2828187, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-2992360, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-3034057, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-3532944, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7723548, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7726514, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7830580, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7889326, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7973175, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7986003, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7986007, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7988876, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-7997176, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8031045, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8058039, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8092826, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8092836, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8153625, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8383113, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8459767, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8460908, http://linkedlifedata.com/resource/pubmed/commentcorrection/8552639-8509339
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
362-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.
pubmed:affiliation
Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
pubmed:publicationType
Journal Article, Comparative Study
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