rdf:type |
|
lifeskim:mentions |
umls-concept:C0001175,
umls-concept:C0019704,
umls-concept:C0032105,
umls-concept:C0035647,
umls-concept:C0035668,
umls-concept:C0200635,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0449435,
umls-concept:C0596382,
umls-concept:C1257890,
umls-concept:C1332714,
umls-concept:C1549054,
umls-concept:C1836233
|
pubmed:issue |
7
|
pubmed:dateCreated |
1996-2-16
|
pubmed:abstractText |
Clinical trials of antiretroviral drugs can take years to complete because the outcomes measured are progression to the acquired immunodeficiency syndrome (AIDS) or death. Trials could be accelerated by the use of end points such as changes in CD4+ lymphocyte counts and plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA and beta 2-microglobulin, but there is uncertainty about whether these surrogate measures are valid predictors of disease progression.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0028-4793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
334
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
426-31
|
pubmed:dateRevised |
2010-3-24
|
pubmed:meshHeading |
pubmed-meshheading:8552144-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8552144-Antiviral Agents,
pubmed-meshheading:8552144-Biological Markers,
pubmed-meshheading:8552144-CD4 Lymphocyte Count,
pubmed-meshheading:8552144-Disease Progression,
pubmed-meshheading:8552144-HIV Infections,
pubmed-meshheading:8552144-HIV-1,
pubmed-meshheading:8552144-Humans,
pubmed-meshheading:8552144-Life Tables,
pubmed-meshheading:8552144-Outcome Assessment (Health Care),
pubmed-meshheading:8552144-RNA, Viral,
pubmed-meshheading:8552144-Regression Analysis,
pubmed-meshheading:8552144-Retrospective Studies,
pubmed-meshheading:8552144-Risk,
pubmed-meshheading:8552144-Zidovudine,
pubmed-meshheading:8552144-beta 2-Microglobulin
|
pubmed:year |
1996
|
pubmed:articleTitle |
Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS.
|
pubmed:affiliation |
Department of Medicine, West Los Angeles Veterans Affairs Medical Center, CA 90073, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|