| pubmed-article:8551261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C0999806 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C0444186 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C0547040 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C0205081 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C0031082 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C1947932 | lld:lifeskim |
| pubmed-article:8551261 | lifeskim:mentions | umls-concept:C1709793 | lld:lifeskim |
| pubmed-article:8551261 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8551261 | pubmed:dateCreated | 1996-2-20 | lld:pubmed |
| pubmed-article:8551261 | pubmed:abstractText | The aim of this study was to examine the efficacy of semi-quantitative polymerase chain reaction (PCR) testing in cervical smears as an adjunct to cytological surveillance in a cohort of women with mild or moderate dyskaryosis. The study population comprised a group of 62 women who underwent twelve months of cytological and colposcopic surveillance as part of a larger randomised prospective study of women with mild and moderate dyskaryosis. Semi-quantitative PCR for HPV-16 DNA was carried out on the initial and twelve month study smears before a large loop excision of the transformation zone (LLETZ) was carried out. Smears from a control population which comprised 167 women without a history of abnormal cervical cytology who were attending family planning and general practitioner clinics for routine cervical smears were tested similarly. The presence of high or intermediate levels of HPV-16 DNA on both the initial and twelve month study smear was positively associated with the identification of cervical intraepithelial neoplasia (CIN) grades II or III in the LLETZ specimen (P = 0.01). While the combination of HPV-16 DNA testing with cytology on a repeat cervical smear improved the selection of women with underlying CIN II/III, there was still a false negative rate of 53%. Twenty-nine women had 'low risk' levels of HPV-16 DNA and mild dyskaryosis or less on both repeat smears indicating suitability for surveillance, but in fact 34% of them had CIN II/III. This study supports the finding reported previously of an association between high and intermediate levels of HPV-16 DNA and CIN II/III.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8551261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8551261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8551261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8551261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8551261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8551261 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8551261 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:8551261 | pubmed:author | pubmed-author:AndersonDD | lld:pubmed |
| pubmed-article:8551261 | pubmed:author | pubmed-author:MannEE | lld:pubmed |
| pubmed-article:8551261 | pubmed:author | pubmed-author:KitchenerHH | lld:pubmed |
| pubmed-article:8551261 | pubmed:author | pubmed-author:JiangGG | lld:pubmed |
| pubmed-article:8551261 | pubmed:author | pubmed-author:FlannellyGG | lld:pubmed |
| pubmed-article:8551261 | pubmed:author | pubmed-author:MelvinWW | lld:pubmed |
| pubmed-article:8551261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8551261 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:8551261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8551261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8551261 | pubmed:pagination | 6-9 | lld:pubmed |
| pubmed-article:8551261 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:meshHeading | pubmed-meshheading:8551261-... | lld:pubmed |
| pubmed-article:8551261 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8551261 | pubmed:articleTitle | Serial quantitation of HPV-16 in the smears of women with mild and moderate dyskaryosis. | lld:pubmed |
| pubmed-article:8551261 | pubmed:affiliation | Wellbeing Centre for the Prevention of Cervical Cancer, Aberdeen Royal Infirmary, University of Aberdeen, Scotland. | lld:pubmed |
| pubmed-article:8551261 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8551261 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8551261 | lld:pubmed |
