| pubmed-article:8550612 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8550612 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8550612 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8550612 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8550612 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:8550612 | lifeskim:mentions | umls-concept:C0063740 | lld:lifeskim |
| pubmed-article:8550612 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8550612 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8550612 | pubmed:dateCreated | 1996-2-20 | lld:pubmed |
| pubmed-article:8550612 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:abstractText | Human involucrin whose gene transcription is directed by a 2456-nucleotide (nt) 5'-noncoding region is a structural component of the epithelial cornified layer. Transient transfection assays demonstrated that this region is transcriptionally active in multiplying keratinocytes and is enhanced by 2 mM CaCl2 treatment. Calcium-independent transcriptional activity and the interaction with the AP-1 transcriptional factor was located on the proximal part (nt -159 to -1) of the 5'-noncoding region. However, CaCl2 responsiveness was mapped to a distal 1185-nt fragment (nt -2456 to -1272). Moreover, this fragment potentiated the Herpes simplex thymidine kinase promoter in normal keratinocytes and is responsive to calcium treatment in a cell type-specific manner. Interestingly, the absence of a 491-nt fragment located between the two enhancer domains (nt -651 to -160) resulted in transcriptional activation in multiplying keratinocytes. This fragment interacts with AP-1 and the YY1 transcriptional silencer. It is concluded that human involucrin 5'-noncoding region contains at least three regulatory domains, a distal CaCl2-responsive enhancer, a putative transcriptional silencer (that interacts with AP-1 and YY1), and a proximal enhancer/promoter (that interacts with AP-1). Thus, this study demonstrates the presence of particular transcriptional factors can potentially regulate the human involucrin expression. | lld:pubmed |
| pubmed-article:8550612 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8550612 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8550612 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8550612 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8550612 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:VegaAA | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:GariglioPP | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:CadenaAA | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:Alvarez-Salas... | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:Lopez-Bayghen... | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:GranadosS ESE | lld:pubmed |
| pubmed-article:8550612 | pubmed:author | pubmed-author:JaveL FLF | lld:pubmed |
| pubmed-article:8550612 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8550612 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8550612 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8550612 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8550612 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8550612 | pubmed:pagination | 512-20 | lld:pubmed |
| pubmed-article:8550612 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:meshHeading | pubmed-meshheading:8550612-... | lld:pubmed |
| pubmed-article:8550612 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8550612 | pubmed:articleTitle | Transcriptional analysis of the 5'-noncoding region of the human involucrin gene. | lld:pubmed |
| pubmed-article:8550612 | pubmed:affiliation | Departamento de Genetica y Biologia Molecular, Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Mexico, Distrito Federal, Mexico. | lld:pubmed |
| pubmed-article:8550612 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8550612 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3713 | entrezgene:pubmed | pubmed-article:8550612 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8550612 | lld:pubmed |
