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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1996-2-21
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pubmed:abstractText |
Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells. These DA-deficient (DA-/-) mice were born at expected frequency but became hypoactive and stopped feeding a few weeks after birth. Midbrain dopaminergic neurons, their projections, and most characteristics of their target neurons in the striatum appeared normal. Within a few minutes of being injected with L-dihdroxyphenylalanine (L-DOPA), the product of TH, the DA-/- mice became more active and consumed more food than control mice. With continued administration of L-DOPA, nearly normal growth was achieved. These studies indicate that DA is essential for movement and feeding, but is not required for the development of neural circuits that control these behaviors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1197-209
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8548806-Adrenergic Fibers,
pubmed-meshheading:8548806-Animals,
pubmed-meshheading:8548806-Animals, Newborn,
pubmed-meshheading:8548806-Behavior, Animal,
pubmed-meshheading:8548806-Dopamine,
pubmed-meshheading:8548806-Dopamine beta-Hydroxylase,
pubmed-meshheading:8548806-Drinking Behavior,
pubmed-meshheading:8548806-Dynorphins,
pubmed-meshheading:8548806-Embryo, Mammalian,
pubmed-meshheading:8548806-Feeding Behavior,
pubmed-meshheading:8548806-Immunohistochemistry,
pubmed-meshheading:8548806-In Situ Hybridization,
pubmed-meshheading:8548806-Levodopa,
pubmed-meshheading:8548806-Mesencephalon,
pubmed-meshheading:8548806-Mice,
pubmed-meshheading:8548806-Mice, Transgenic,
pubmed-meshheading:8548806-Mutation,
pubmed-meshheading:8548806-Neostriatum,
pubmed-meshheading:8548806-Neurons,
pubmed-meshheading:8548806-Norepinephrine,
pubmed-meshheading:8548806-Substance P,
pubmed-meshheading:8548806-Transgenes,
pubmed-meshheading:8548806-Tyrosine 3-Monooxygenase
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pubmed:year |
1995
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pubmed:articleTitle |
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle 98195-7370, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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