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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1996-2-20
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pubmed:abstractText |
Gender differences and the effect of chronic haloperidol on the rat brain dopamine transporter is reported. The density of striatal dopamine transporter sites labelled with [3H]GBR 12935, and of substantia nigra dopamine transporter mRNA measured by in situ hybridization were higher in female compared to male rats whereas striatal D2 specific binding labelled with [3H]spiperone was not significantly higher. Daily haloperidol treatment (1 mg/kg, i.p.) for 21 days increased striatal [3H]spiperone specific binding but left unchanged striatal [3H]GBR 12935 binding density and affinity as well as substantia nigra dopamine transporter mRNA levels. A reduce clearance rate of dopamine in the striatum after acute and chronic haloperidol was previously reported; the present results indicate that this may occur without changes in the sites of dopamine transport or in gene expression of this transporter.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/GBR 12935,
http://linkedlifedata.com/resource/pubmed/chemical/Haloperidol,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Spiperone
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
692
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8548314-Animals,
pubmed-meshheading:8548314-Brain Chemistry,
pubmed-meshheading:8548314-Carrier Proteins,
pubmed-meshheading:8548314-Dopamine,
pubmed-meshheading:8548314-Dopamine Antagonists,
pubmed-meshheading:8548314-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:8548314-Dopamine Uptake Inhibitors,
pubmed-meshheading:8548314-Female,
pubmed-meshheading:8548314-Haloperidol,
pubmed-meshheading:8548314-In Situ Hybridization,
pubmed-meshheading:8548314-Male,
pubmed-meshheading:8548314-Membrane Glycoproteins,
pubmed-meshheading:8548314-Membrane Transport Proteins,
pubmed-meshheading:8548314-Neostriatum,
pubmed-meshheading:8548314-Nerve Tissue Proteins,
pubmed-meshheading:8548314-Piperazines,
pubmed-meshheading:8548314-RNA, Messenger,
pubmed-meshheading:8548314-Rats,
pubmed-meshheading:8548314-Rats, Sprague-Dawley,
pubmed-meshheading:8548314-Receptors, Dopamine D2,
pubmed-meshheading:8548314-Sex Characteristics,
pubmed-meshheading:8548314-Spiperone,
pubmed-meshheading:8548314-Substantia Nigra
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pubmed:year |
1995
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pubmed:articleTitle |
Brain dopamine transporter: gender differences and effect of chronic haloperidol.
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pubmed:affiliation |
School of Pharmacy, Laval University, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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