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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1996-2-22
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pubmed:abstractText |
Heavy-chain diseases (HCDs) are human lymphoproliferative neoplasias that are characterized by the secretion of truncated immunoglobulin heavy chains devoid of light chains. We have previously proposed--by analogy to the process by which mutated growth factor receptors can be oncogenic--that because the genetic defects in HCDs result in the production of abnormal membrane-associated heavy chains lacking an antigen-binding domain, these abnormal B-cell antigen receptors might engage in ligand-independent signalling. Normal pre-B-cell development requires the presence of the pre-B-cell receptor, formed by the association of mu heavy chains with two polypeptides--so-called surrogate light chains, Vpre-B and lambda 5--that are homologous to the variable and constant portions of immunoglobulin light chains, respectively. To assess whether amino-terminal truncation of membrane-associated heavy chains results in their constitutive activation, we have examined the ability of a HCD-associated mu protein to promote pre-B-cell development in transgenic mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD43,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Light Chains...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin gamma-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin mu-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/heavy chain disease proteins, human
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1140-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8548286-Animals,
pubmed-meshheading:8548286-Antigens, CD,
pubmed-meshheading:8548286-Antigens, CD43,
pubmed-meshheading:8548286-B-Lymphocytes,
pubmed-meshheading:8548286-Base Sequence,
pubmed-meshheading:8548286-Cell Differentiation,
pubmed-meshheading:8548286-DNA Primers,
pubmed-meshheading:8548286-Gene Deletion,
pubmed-meshheading:8548286-Heavy Chain Disease,
pubmed-meshheading:8548286-Hematopoietic Stem Cells,
pubmed-meshheading:8548286-Immunoglobulin Light Chains,
pubmed-meshheading:8548286-Immunoglobulin Light Chains, Surrogate,
pubmed-meshheading:8548286-Immunoglobulin gamma-Chains,
pubmed-meshheading:8548286-Immunoglobulin mu-Chains,
pubmed-meshheading:8548286-Membrane Glycoproteins,
pubmed-meshheading:8548286-Mice,
pubmed-meshheading:8548286-Mice, Inbred BALB C,
pubmed-meshheading:8548286-Mice, Transgenic,
pubmed-meshheading:8548286-Molecular Sequence Data,
pubmed-meshheading:8548286-Peptide Fragments,
pubmed-meshheading:8548286-Sialoglycoproteins
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pubmed:year |
1995
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pubmed:articleTitle |
Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.
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pubmed:affiliation |
Institut Cochin de Génétique Moléculaire, Unité INSERM 257, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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