Linked Life Data

8548067

Source:http://linkedlifedata.com/resource/pubmed/id/8548067

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-2-22
pubmed:abstractText
It has been stated that two terminal carbohydrates from polysaccharide complexes which are on the surface of human epithelial tissues, namely, alpha-D-glucose and N-acetylneuramino acid bound with subterminal galactose via alpha 2-->3-bond (NeuAc alpha 2-->3 Gal), may serve receptors for Mycoplasma fermentans adhesion on human epithelial cells. M. fermentans shows high selectivity to these receptors, though very low affinity. The latter, probably, explains why this mycoplasma is able to infect only the limited number of peoples. In the authors' opinion people with the lower content of glucose in urine, as well as those who suffer from diseases associated with hypothalamo-hypophyseal insufficiency are subjected to infection with M. fermentans. People with normal (3.33-5.55 mM) and elevated alpha-D-glucose content in blood and in urine are not susceptible to this mycoplasma. Results of the research carried have shown that alpha-D-glucose solutions of definite concentration may be used to eliminate M. fermentans from the urogenital tract of people who have it. The ability of M. fermentans to discriminate terminal structure of NeuAc alpha 2-->3 Gal provides it with the possibility to adhere human immunodeficiency virus virions on its cells as glycoprotein (gp120) of that virus has among its own oligosaccharides certain glycopolymers of the similar terminal structure. Then M. fermentans transports the virions directly to target cells for this virus. The target cells express receptor CD4 glycolized by oligosaccharides of the mentioned terminal structure. It provides adhesion of the mycoplasma on the receptor.
pubmed:language
ukr
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1028-0987
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Carbohydrate receptors for Mycoplasma fermentans adhesion on human epithelial tissues].
pubmed:publicationType
Journal Article, English Abstract