Linked Life Data

8547717

Source:http://linkedlifedata.com/resource/pubmed/id/8547717

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-2-22
pubmed:abstractText
Electron acceptors in biological systems, termed "oxidants", have been associated with numerous cytopathic conditions. In particular, oxygen-derived free radicals have been shown to induce various subcellular oxidative injuries which can lead to different types of pathologies. It has also been suggested that oxidative stress induced by xenobiotics can determine specific subcellular alterations in in vitro models. An oxidative imbalance in cells seems in fact to affect intracellular functions including the expression of some growth factor surface receptors. In this work, we observed a specific early alteration of the microfilament system and the microtubular network induced in K562 cells by oxidative stress. In particular, we hypothesize that oxidative imbalance could lead to an impairment of the expression of these receptors, such as transferrin receptors, via a modification of the cytoskeleton. This could represent a general mechanism by which a modification of receptor regulation can lead to cell aging, injury or death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1121-760X
pubmed:author
pubmed:issnType
Print
pubmed:volume
38 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-100
pubmed:dateRevised
2008-8-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Cytoskeletal oxidative changes lead to alterations of specific cell surface receptors.
pubmed:affiliation
Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy.
pubmed:publicationType
Journal Article