Linked Life Data

8546274

Source:http://linkedlifedata.com/resource/pubmed/id/8546274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-2-13
pubmed:abstractText
We have studied the induction of nitric oxide during late allergic responses, using a guinea pig model of trimellitic anhydride (TMA)-induced airway allergy. TMA is a low molecular weight chemical which can cause occupational asthma. The activity of nitric oxide synthase (NOS) was investigated by the detection of 3H-labeled citrulline formation from 3H-labeled arginine. In sensitized animals, challenge with TMA conjugated to guinea pigs albumin (TMA-GPSA) increased the activity of Ca(2+)-independent NOS (inducible NOS; iNOS) in lung and bronchial tissues at 15-17 h after challenge compared to nonsensitized animals. The induction of iNOS activity was associated with an associated with an increased level of nitrite, an end metabolite of the l-arginine-NO pathway, in bronchoalveolar lavage fluid. In contrast to iNOS, the activity of Ca(2+)-dependent NOS (constitutive NOS; cNOS) was not affected by the allergen challenge. These results demonstrate that iNOS in bronchial tissue is induced late after allergen challenge in sensitized guinea pig.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0105-4538
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Induction of nitric oxide synthase in a model of allergic occupational asthma.
pubmed:affiliation
Department of Clinical Pharmacology, Gothenburg University, Sahlgrens Hospital, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't