Linked Life Data

8544968

Source:http://linkedlifedata.com/resource/pubmed/id/8544968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-2-14
pubmed:abstractText
We examined the effect of sodium valproate (VPA) on monoamine synthesis in the mouse cerebral cortex by measuring the accumulation of L-3,4-dihydroxyphenylalanine and 5-hydroxytryptophan following inhibition of aromatic L-amino acid decarboxylase. Treatment with VPA decreased catecholamine synthesis, in a dose-dependent manner, with maximum inhibition 60 min following treatment. Muscimol, a GABAA receptor agonist, also decreased catecholamine synthesis, although baclofen, a GABAB receptor agonist, did not. Picrotoxin, a GABAA receptor antagonist, inhibited the VPA-induced decrease in catecholamine synthesis. However, serotonin synthesis was not significantly changed by VPA. These results suggest that acute treatment with VPA reduces the synthesis of catecholamines via GABAA receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0302-282X
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effect of acute treatment with sodium valproate on catecholamine and serotonin synthesis in mouse cerebral cortex.
pubmed:affiliation
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't