| pubmed-article:8543652 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C0008046 | lld:lifeskim |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C0037925 | lld:lifeskim |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C0021792 | lld:lifeskim |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8543652 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8543652 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8543652 | pubmed:dateCreated | 1996-2-13 | lld:pubmed |
| pubmed-article:8543652 | pubmed:abstractText | To investigate the role of retinoic acid (RA) in the development of interneurons in the spinal cord, we examined the expression of cellular retinoic acid binding protein type I (CRABP I). The earliest developing interneurons in the chick spinal cord can be divided into two major groups: circumferential (C) neurons and primitive longitudinal (PL) neurons. In brachial segments, both types of interneurons began to express CRABP I at stage (st.) 13+ of the V. Hamburger and H.L. Hamilton (1951, J. Morphol. 88:49-92) stage series, which is before the onset of axonogenesis. Subsequently, with the onset of axonal outgrowth, C neurons and PL neurons expressed CRABP I in their cell bodies, axons, and growth cones. The expression of CRABP I was developmentally regulated. CRABP I immunoreactivity gradually decreased after st. 36 (embryonic day [E] 10) such that no interneurons expressed this protein by E21. The transient expression of CRABP I during a period of intensive axonal growth suggested that RA may be involved in the development of interneurons. To test this idea, we implanted an all-trans RA-containing ion exchange bead into either rostral segments of the spinal cord at st. 12-13 or into caudal segments at st. 15-16, all stages that are well before the appearance of CRABP-I-positive neurons in these segments. In the RA-treated spinal cord, increased numbers of pyknotic cells were found predominantly in dorsal regions, presumably reflecting the death of neuroepithelial cells, C neurons and premigratory neural crest cells. Surviving C neurons in the RA-treated spinal cord extended their axons ventrally toward the floor plate as in control embryos. PL neurons also projected their axons rostrally or caudally in the RA-treated spinal cord, similarly to control embryos. However, the proportion of caudally projecting PL neurons was significantly increased in segments rostral to the RA-containing bead. These results suggest that RA may regulate the survival and axonal orientation (directionality) of subpopulations of spinal interneurons. | lld:pubmed |
| pubmed-article:8543652 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8543652 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8543652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543652 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8543652 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8543652 | pubmed:issn | 0021-9967 | lld:pubmed |
| pubmed-article:8543652 | pubmed:author | pubmed-author:YamaguchiKK | lld:pubmed |
| pubmed-article:8543652 | pubmed:author | pubmed-author:ShigaTT | lld:pubmed |
| pubmed-article:8543652 | pubmed:author | pubmed-author:OppenheimR... | lld:pubmed |
| pubmed-article:8543652 | pubmed:author | pubmed-author:GaurV PVP | lld:pubmed |
| pubmed-article:8543652 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8543652 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8543652 | pubmed:volume | 360 | lld:pubmed |
| pubmed-article:8543652 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8543652 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8543652 | pubmed:pagination | 463-74 | lld:pubmed |
| pubmed-article:8543652 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:meshHeading | pubmed-meshheading:8543652-... | lld:pubmed |
| pubmed-article:8543652 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8543652 | pubmed:articleTitle | The development of interneurons in the chick embryo spinal cord following in vivo treatment with retinoic acid. | lld:pubmed |
| pubmed-article:8543652 | pubmed:affiliation | Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1010, USA. | lld:pubmed |
| pubmed-article:8543652 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8543652 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8543652 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8543652 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8543652 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8543652 | lld:pubmed |
