| pubmed-article:8543157 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:8543157 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:8543157 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:8543157 | pubmed:dateCreated | 1996-2-9 | lld:pubmed |
| pubmed-article:8543157 | pubmed:abstractText | Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix (HLH) factor that is thought to act as a negative regulator of neurogenesis. To directly investigate the functions of HES-1 in mammalian embryogenesis, we performed a targeted disruption of the HES-1 locus. Mice homozygous for the mutation exhibited severe neurulation defects and died during gestation or just after birth. In the developing brain of HES-1-null embryos, expression of the neural differentiation factor Mash-1 and other neural HLH factors was up-regulated and postmitotic neurons appeared prematurely. These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis. | lld:pubmed |
| pubmed-article:8543157 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8543157 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543157 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8543157 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8543157 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8543157 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:8543157 | pubmed:author | pubmed-author:NakanishiSS | lld:pubmed |
| pubmed-article:8543157 | pubmed:author | pubmed-author:IshibashiMM | lld:pubmed |
| pubmed-article:8543157 | pubmed:author | pubmed-author:ShiotaKK | lld:pubmed |
| pubmed-article:8543157 | pubmed:author | pubmed-author:KageyamaRR | lld:pubmed |
| pubmed-article:8543157 | pubmed:author | pubmed-author:GuillemotFF | lld:pubmed |
| pubmed-article:8543157 | pubmed:author | pubmed-author:AngS LSL | lld:pubmed |
| pubmed-article:8543157 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8543157 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8543157 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8543157 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8543157 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8543157 | pubmed:pagination | 3136-48 | lld:pubmed |
| pubmed-article:8543157 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8543157 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8543157 | pubmed:articleTitle | Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. | lld:pubmed |
| pubmed-article:8543157 | pubmed:affiliation | Institute for Immunology, Kyoto University Faculty of Medicine, Japan. | lld:pubmed |
| pubmed-article:8543157 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8543157 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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