|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0024660,
umls-concept:C0027794,
umls-concept:C0041904,
umls-concept:C0086222,
umls-concept:C0162493,
umls-concept:C0181586,
umls-concept:C0205082,
umls-concept:C0205252,
umls-concept:C0332453,
umls-concept:C0599851,
umls-concept:C0599894,
umls-concept:C0814002,
umls-concept:C1415725,
umls-concept:C1512130,
umls-concept:C1521761,
umls-concept:C1521840,
umls-concept:C1534709,
umls-concept:C1705733,
umls-concept:C2827371
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|
pubmed:issue |
24
|
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pubmed:dateCreated |
1996-2-9
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|
pubmed:abstractText |
Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix (HLH) factor that is thought to act as a negative regulator of neurogenesis. To directly investigate the functions of HES-1 in mammalian embryogenesis, we performed a targeted disruption of the HES-1 locus. Mice homozygous for the mutation exhibited severe neurulation defects and died during gestation or just after birth. In the developing brain of HES-1-null embryos, expression of the neural differentiation factor Mash-1 and other neural HLH factors was up-regulated and postmitotic neurons appeared prematurely. These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E(spl) region transcript mdelta...,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/hairy protein, insect
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3136-48
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8543157-Animals,
pubmed-meshheading:8543157-Base Sequence,
pubmed-meshheading:8543157-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:8543157-DNA Primers,
pubmed-meshheading:8543157-DNA-Binding Proteins,
pubmed-meshheading:8543157-Drosophila Proteins,
pubmed-meshheading:8543157-Embryonic and Fetal Development,
pubmed-meshheading:8543157-Helix-Loop-Helix Motifs,
pubmed-meshheading:8543157-Insect Hormones,
pubmed-meshheading:8543157-Insect Proteins,
pubmed-meshheading:8543157-Mice,
pubmed-meshheading:8543157-Molecular Sequence Data,
pubmed-meshheading:8543157-Nervous System,
pubmed-meshheading:8543157-Neural Tube Defects,
pubmed-meshheading:8543157-Repressor Proteins,
pubmed-meshheading:8543157-Transcription Factors,
pubmed-meshheading:8543157-Up-Regulation
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pubmed:year |
1995
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pubmed:articleTitle |
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
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pubmed:affiliation |
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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