Linked Life Data

8542167

Source:http://linkedlifedata.com/resource/pubmed/id/8542167

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-2-13
pubmed:abstractText
We used published data for the elastic properties of a 2-mm outer-diameter canine bronchus and assumed values for the thickness of the wall components and lung parenchymal shear modulus to estimate the load on airway smooth muscle and its effect on airway narrowing. The following relationships were calculated: (1) luminal and smooth muscle radii of curvature and transmural pressure; (2) the isovolume, transmural pressures developed by the smooth muscle to narrow the lumen at distending pressures of 20, 10, 5, and 2 cm H2O; (3) the equilibrium tension developed by, and thus the load on, the airway smooth muscle as a function of smooth muscle length during isovolume bronchoconstriction. From these calculations a smooth muscle length-tension diagram was drawn allowing the interactions between submucosal thickening, peribronchial thickening, load, and smooth muscle contractility to be analyzed. The analysis indicates that: (1) the load on smooth muscle decreases by more than an order of magnitude between a distending pressure of 20 and 2 cm H2O; (2) increasing smooth muscle contractility has more effect at large rather than at small distending pressures; (3) peribronchial inflammation decreases both load and the slope of the relationship between peribronchial and pleural pressures. Decreases in load may be an important mechanism producing excessive bronchoconstriction in asthma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
A theoretical analysis of the effect of airway smooth muscle load on airway narrowing.
pubmed:affiliation
Respiratory Health Network of Centres of Excellence, Meakins-Christie Laboratories, Montreal Chest Institute, Royal Victoria Hospital, McGill University, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't