Linked Life Data

8540747

Source:http://linkedlifedata.com/resource/pubmed/id/8540747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-2-6
pubmed:abstractText
Herpes simplex virus type 1 (HSV-1) reactivates from the nervous system and causes recurrent disease in end organs such as the eye and the lips. We found that the beta-adrenergic receptor blocker, propranolol, reduces HSV-1 reactivation in an animal model. Mice latent for McKrae strain HSV-1 were injected with propranolol or saline once a day for 3 successive days, and subjected to a brief period of hyperthermia on the second day to induce reactivation. Twenty-four hours after the third injection, swabs of the ocular surface and homogenates of the corneas and trigeminal ganglia were analyzed for the presence of infectious virus and viral DNA. Treatment with propranolol significantly decreased the appearance of infectious virus in the tear film, cornea, and trigeminal ganglia (P < 0.05, chi 2-test). The results suggest a possible new pharmacologic approach to suppressing herpesvirus reactivation in the nervous system and thereby preventing recurrent disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0166-3542
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Propranolol suppresses reactivation of herpesvirus.
pubmed:affiliation
LSU Eye Center, Louisiana State University Medical Center, School of Medicine, New Orleans 70112, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't