Linked Life Data

8540712

Source:http://linkedlifedata.com/resource/pubmed/id/8540712

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-2-6
pubmed:abstractText
Cefodizime is a new expanded-spectrum cephalosporin for parenteral use which possesses a broad antibacterial spectrum and potent antibacterial activity and is stable against most beta-lactamases. The aim of this study was to assess the pharmacokinetics of cefodizime, administered intravenously, over the dose range of 0.5 to 3.0 g in healthy volunteers. Concentrations of cefodizime in the serum and urine were determined by high-performance liquid chromatography. The area under the concentration-time curve from 0 h to infinity and the amount of drug excreted in urine from 0 to 34 h increased in a linear, dose-dependent manner with increasing doses of antibiotic from 0.5 to 3.0 g. Mean concentrations of cefodizime in plasma at the end of infusion increased from 97 to 440 mg liter-1 over the dose range 0.5 to 3.0 g and displayed a slight deviation from linearity at doses in excess of 2.0 g. Total plasma clearance (3.11 liters h-1), volume of distribution at steady state (10.5 liters), terminal elimination half-life (3.3 h), and renal clearance (1.91 liters h-1) remained constant over the doses administered. Cefodizime was well tolerated in this study.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-1003329, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-1473357, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-2032473, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-2074251, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-2074253, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-2074258, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-3032885, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-3450392, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-6275779, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-6284519, http://linkedlifedata.com/resource/pubmed/commentcorrection/8540712-7053242
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2037-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Pharmacokinetics of cefodizime following single doses of 0.5, 1.0, 2.0, and 3.0 grams administered intravenously to healthy volunteers.
pubmed:affiliation
Roussel Uclaf, Romainville, France.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't