Linked Life Data

8539782

Source:http://linkedlifedata.com/resource/pubmed/id/8539782

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1996-2-6
pubmed:abstractText
Since it has been demonstrated that corticosteroid-binding globulin (CBG) plays a role in intracellar steroidal actions in target cells, the expression of CBG mRNA as the measure of CBG expression was investigated in human endometrial cancers in order to assess the biological implications of CBG. The level of CBG mRNA was analyzed using competitive reverse transcription-polymerase chain reaction-Southern blot analysis. While the level of CBG mRNA was significantly (P < 0.01) higher in secretory phase endometrium than in early and late proliferative phase endometrium, the level of CBG mRNA tended to decrease with advanced dedifferentiation of endometrial cancers as compared to normal endometrium. These results suggest that dedifferentiation of endometrial cancers induces a reduction in intracellular CBG synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0039-128X
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
720-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers.
pubmed:affiliation
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
pubmed:publicationType
Journal Article