|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1996-2-6
|
|
pubmed:abstractText |
Thirty-nine previously treated Hodgkin's disease (HD) patients were immunized with 7-valent pneumococcal conjugate vaccine (7-OMPC) followed by one dose of 23-valent polysaccharide pneumococcal vaccine (23-PS). To determine the priming effect of 7-OMPC vaccine, their antibody responses to six serotypes contained in both vaccines were compared to those of 57 HD patients who received 23-PS vaccine only. The geometric mean antibody concentrations after immunization with 23-PS vaccine were significantly higher for five of the six measured serotypes in HD patients primed with 7-OMPC vaccine compared with responses in HD patients who received 23-PS vaccine only. The mean of the six antibody concentrations was significantly higher for the primed group at 12.5 micrograms/mL and 7.76 micrograms/mL, respectively (P = .015). Priming with a conjugate vaccine should be considered as a strategy to protect high-risk adults.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-1899
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
173
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
256-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:8537671-Adolescent,
pubmed-meshheading:8537671-Adult,
pubmed-meshheading:8537671-Aged,
pubmed-meshheading:8537671-Antibodies, Viral,
pubmed-meshheading:8537671-Bacterial Capsules,
pubmed-meshheading:8537671-Bacterial Vaccines,
pubmed-meshheading:8537671-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8537671-Female,
pubmed-meshheading:8537671-Hodgkin Disease,
pubmed-meshheading:8537671-Humans,
pubmed-meshheading:8537671-Immunization,
pubmed-meshheading:8537671-Immunoglobulin G,
pubmed-meshheading:8537671-Male,
pubmed-meshheading:8537671-Middle Aged,
pubmed-meshheading:8537671-Pneumococcal Infections,
pubmed-meshheading:8537671-Pneumococcal Vaccines,
pubmed-meshheading:8537671-Polysaccharides, Bacterial,
pubmed-meshheading:8537671-Random Allocation,
pubmed-meshheading:8537671-Serotyping,
pubmed-meshheading:8537671-Streptococcus pneumoniae,
pubmed-meshheading:8537671-Vaccines, Conjugate
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Pneumococcal conjugate vaccine primes for antibody responses to polysaccharide pneumococcal vaccine after treatment of Hodgkin's disease.
|
|
pubmed:affiliation |
Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
