| pubmed-article:8537375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0812313 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0032131 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0253050 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8537375 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8537375 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:8537375 | pubmed:dateCreated | 1996-2-8 | lld:pubmed |
| pubmed-article:8537375 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8537375 | pubmed:abstractText | The immediate early gene, junB, is induced by interleukin-6 (IL-6) in plasmacytomas. In order to identify enhancers that mediate this effect, we cloned upstream and downstream sequences flanking the gene into a luciferase reporter gene vector containing the junB promoter and evaluated the IL-6 inducibility of these sequences by transient expression in an IL-6-dependent plasmacytoma cell line. Although a 6.5-kilobase fragment of upstream flanking sequence did not increase the IL-6 inducibility of the junB promoter, a 222-base pair fragment was identified in 2.1 kilobases of down-stream flanking sequence that both up-regulates the promoter and confers inducibility by IL-6. Point mutation of an acute phase response factor (APRF) site within this region significantly reduced up-regulation of the promoter in cells grown continuously in IL-6, as well as inducibility upon restimulation of cells with IL-6 after withdrawal from the growth factor. Point mutation of an NF-kappa B site sharing five nucleotides with the APRF site reduced up-regulation of the promoter but not inducibility by IL-6, whereas mutation of two other NF-kappa B sites in the 222-base pair fragment had no effect on expression. Western blotting of nuclear proteins purified by DNA affinity chromatography revealed inducible binding of Stat3 and constitutive binding of NF-kappa B p65 to the APRF/NF-kappa B site. | lld:pubmed |
| pubmed-article:8537375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8537375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8537375 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8537375 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8537375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8537375 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8537375 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8537375 | pubmed:author | pubmed-author:BrownR TRT | lld:pubmed |
| pubmed-article:8537375 | pubmed:author | pubmed-author:AdesI ZIZ | lld:pubmed |
| pubmed-article:8537375 | pubmed:author | pubmed-author:NordanR PRP | lld:pubmed |
| pubmed-article:8537375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8537375 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:8537375 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:8537375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8537375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8537375 | pubmed:pagination | 31129-35 | lld:pubmed |
| pubmed-article:8537375 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8537375 | pubmed:meshHeading | pubmed-meshheading:8537375-... | lld:pubmed |
| pubmed-article:8537375 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8537375 | pubmed:articleTitle | An acute phase response factor/NF-kappa B site downstream of the junB gene that mediates responsiveness to interleukin-6 in a murine plasmacytoma. | lld:pubmed |
| pubmed-article:8537375 | pubmed:affiliation | Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:8537375 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:16477 | entrezgene:pubmed | pubmed-article:8537375 | lld:entrezgene |
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