Linked Life Data

8537016

Source:http://linkedlifedata.com/resource/pubmed/id/8537016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-2-6
pubmed:abstractText
Osteoporosis seen in aged individuals is represented by the reduced bone mass most likely resulting from decreased bone formation by osteoblasts. To examine whether aging causes a decrease in osteoblast activity, calvarial osteoblasts were isolated from aged rats (AOB) and studied for the capacity of the cells to form mineralized bone-like nodules in comparison with that of fetal calvarial osteoblasts (FOB). There were no significant differences in basal mineralized bone-like nodule formation determined by quantifying the size of the nodules which were formed in the cultures of AOB and FOB. However, the responsiveness of AOB to growth factors was profoundly reduced. AOB showed only marginal increase in mineralized bone-like nodule formation and growth in response to basic fibroblast growth factor (bFGF). On the other hand, bFGF markedly promoted mineralized bone-like nodule formation and proliferation in FOB. These results suggest that decreased responsiveness to local osteotropic growth factors such as bFGF might account for the reduced bone formation by aged osteoblasts, which in turn leads to the loss of bone mass characteristic for senile osteoporosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-324X
pubmed:author
pubmed:issnType
Print
pubmed:volume
41 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Decreased mitogenic and osteogenic responsiveness of calvarial osteoblasts isolated from aged rats to basic fibroblast growth factor.
pubmed:affiliation
Division of Molecular Cell Biology, Tokyo Medical and Dental University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't