| pubmed-article:8536387 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0279328 | lld:lifeskim |
| pubmed-article:8536387 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8536387 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8536387 | pubmed:dateCreated | 1996-2-8 | lld:pubmed |
| pubmed-article:8536387 | pubmed:abstractText | We investigated the secretion of TNF-alpha by monocytes and macrophages derived from the peripheral blood, spleen, and lungs after a single exposure to a therapeutic profile of hyperbaric oxygen (HBO). Rats were exposed for 90 min to either 100% oxygen at 0.28 MPa (2.8 atmospheres absolute) or air. Immediately after exposure, mononuclear cells were isolated from blood, spleen, and lungs and cultured for 18 h. The secretion of TNF-alpha from the cultured monocytes/macrophages was determined with and without stimulation with lipopolysaccharide (LPS). Exposure to hyperbaric oxygen induced a significant increase in the spontaneous ex vivo secretion of TNF-alpha (without LPS) by mononuclear cells from the blood, spleen, and lung (P < 0.05 from air controls). Stimulation with LPS after exposure to HBO induced a significant increase in TNF-alpha secretion by lung and spleen macrophages compared with air controls (P < 0.05). However, absolute TNF-alpha levels were not significantly higher than those achieved 'spontaneously' in macrophages exposed to HBO without LPS. Stimulation with LPS induced a marked increase in secretion of TNF-alpha from blood monocytes after exposure to air, but not after exposure to HBO. These results provide evidence in support of a role played by TNF-alpha in mediating HBO effects on different tissues and their immune responses. | lld:pubmed |
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| pubmed-article:8536387 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8536387 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8536387 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8536387 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8536387 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8536387 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:8536387 | pubmed:author | pubmed-author:LahatNN | lld:pubmed |
| pubmed-article:8536387 | pubmed:author | pubmed-author:KinartyAA | lld:pubmed |
| pubmed-article:8536387 | pubmed:author | pubmed-author:BittermanHH | lld:pubmed |
| pubmed-article:8536387 | pubmed:author | pubmed-author:BittermanNN | lld:pubmed |
| pubmed-article:8536387 | pubmed:author | pubmed-author:YanivNN | lld:pubmed |
| pubmed-article:8536387 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8536387 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:8536387 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8536387 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8536387 | pubmed:pagination | 655-9 | lld:pubmed |
| pubmed-article:8536387 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8536387 | pubmed:meshHeading | pubmed-meshheading:8536387-... | lld:pubmed |
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| pubmed-article:8536387 | pubmed:meshHeading | pubmed-meshheading:8536387-... | lld:pubmed |
| pubmed-article:8536387 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8536387 | pubmed:articleTitle | Exposure to hyperbaric oxygen induces tumour necrosis factor-alpha (TNF-alpha) secretion from rat macrophages. | lld:pubmed |
| pubmed-article:8536387 | pubmed:affiliation | Israel Naval Medical Institute, Immunological Research Unit, Haifa, Israel. | lld:pubmed |
| pubmed-article:8536387 | pubmed:publicationType | Journal Article | lld:pubmed |
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