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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1996-2-2
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pubmed:abstractText |
Reverse transcriptase (RT) converts the single-stranded RNA genome of a retrovirus into a double-stranded DNA copy for integration into the host genome. This process requires ribonuclease H as well as RNA- and DNA-directed DNA polymerase activities. Although the overall organization of HIV-1 RT is known from previously reported crystal structures, no structure of a complex including a metal ion, which is essential for its catalytic activity, has been reported.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0969-2126
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
3
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
879-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8535782-Amino Acid Sequence,
pubmed-meshheading:8535782-Animals,
pubmed-meshheading:8535782-Binding Sites,
pubmed-meshheading:8535782-Crystallography, X-Ray,
pubmed-meshheading:8535782-DNA Primers,
pubmed-meshheading:8535782-Deoxyribonucleotides,
pubmed-meshheading:8535782-HIV-1,
pubmed-meshheading:8535782-Metals,
pubmed-meshheading:8535782-Mice,
pubmed-meshheading:8535782-Models, Molecular,
pubmed-meshheading:8535782-Molecular Sequence Data,
pubmed-meshheading:8535782-Moloney murine leukemia virus,
pubmed-meshheading:8535782-Protein Conformation,
pubmed-meshheading:8535782-RNA-Directed DNA Polymerase,
pubmed-meshheading:8535782-Ribonucleoproteins,
pubmed-meshheading:8535782-Sequence Alignment
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pubmed:year |
1995
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pubmed:articleTitle |
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.
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pubmed:affiliation |
Waksman Institute, Rutgers University, Piscataway, NJ 08855, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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