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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
1996-2-8
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|
pubmed:abstractText |
Activity of H(+)-ATPase of Trypanosoma cruzi (RA strain) submitochondrial particles is increased in parasites which have a low spermine content caused by growing in a polyamine free medium or in a medium containing inhibitors of polyamine synthesis. Under these conditions, the proliferation rate is markedly decreased. Kinetics of the enzyme inhibition by spermine indicates a non-competitive inhibition. Spermine, through its action on the H(+)-ATPase hydrophobic environment, affects the enzyme activity. Together with the ATPase protein inhibitor, this could be a mechanism regulating ATP levels needed for the parasite proliferation.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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|
pubmed:issn |
0145-5680
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
861-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8535180-Animals,
pubmed-meshheading:8535180-Cycloheximide,
pubmed-meshheading:8535180-Eflornithine,
pubmed-meshheading:8535180-Kinetics,
pubmed-meshheading:8535180-Mitochondria,
pubmed-meshheading:8535180-Proton-Translocating ATPases,
pubmed-meshheading:8535180-Putrescine,
pubmed-meshheading:8535180-Spermidine,
pubmed-meshheading:8535180-Spermine,
pubmed-meshheading:8535180-Submitochondrial Particles,
pubmed-meshheading:8535180-Trypanosoma cruzi
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pubmed:year |
1995
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|
pubmed:articleTitle |
Spermine action on mitochondrial H(+)-ATPase activity and proliferation rate of Trypanosoma cruzi.
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pubmed:affiliation |
Departamento de Bioquímica, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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